CircleDNA is powered by the most advanced Whole Exome Sequencing (WES) technology, for accurate results you can trust.

Whole Exome Sequencing Technology

Your DNA, your (full) health story

Whole Exome Sequencing (WES) is the latest in DNA analytic technology used by top medical groups and leading research centres, such as the UK’s NHS, Harvard University, and Stanford University. It’s a state-of-the-art tool that allows rapid sequencing of large amounts of DNA information.

Imagine that every gene is like a book. Traditional genotyping technology analyses your genes by looking at the equivalent of just a few sentences – but without reading the entire book, you won’t know the full story of what’s happening. With Whole Exome Sequencing (WES) technology, we’re able to produce reports that summarize the whole book of your health – not just a few sentences.


Why read just a sentence when you can read the whole book?


Traditional Genotyping Technology

As an example, recreational tests only look at a few variants of the BRCA 1/2 gene, which creates a high likelihood of producing a false-positive result.

Whole Exome Sequencing Technology

Meanwhile, CircleDNA looks at the whole “book” for the BRCA 1/2 gene, covering 5,791 known variants that affect your risk of breast and ovarian cancer.

Number of genetic data points

Hundreds of thousands

> 31 million

Sampling data volume

Dozens of MB

Several GB


Microarray scanner

Novaseq (next generation sequencing)

Ability to detect new mutations?



Powered by the world’s most advanced DNA technology

Whole Exome Sequencing

CircleDNA’s WES technology conducts a full scan on all your protein-coding genes, providing you with comprehensive and accurate results


Circle Exome

700K data points

50x more than 23andme

31M data points

50x more than 23andme

Our laboratory

All samples submitted to CircleDNA are processed in our own internationally accredited laboratory with WES technology.

We utilise NovaSeqTM 6000 systems, manufactured in the USA, by Illumina — the global market leader in DNA sequencing equipment.

Analytical Accuracy


Highest International Laboratory Quality Standards

International Accreditation


Developed by global leaders in DNA sequencing

Prof. Michael M Yang, PhD

Prof. Michael M Yang, PhD

VP (Research and Technology), Prenetics Yeung Kin-Man Chair Professor of Biomedical Sciences, City University of Hong Kong

Prof. Stephen Tsui, PhD

Prof. Stephen Tsui, PhD

Head of Division of Genomics and Bioinformatics, The Chinese University of Hong Kong

Dr. Lawrence Tzang, PhD

Dr. Lawrence Tzang, PhD

Chief Scientific Officer & Co-founder, Prenetics Founding Member, Hong Kong Society for Behavioural and Neural Genetics

Dr. Senthil Sundaram, MD

Dr. Senthil Sundaram, MD

Chief Clinical Officer, Prenetics Genetic Researcher, National Institute of Health

Our global awards