Technology

CircleDNA is powered by the most advanced Whole Exome Sequencing (WES) technology, for accurate results you can trust.

Whole Exome Sequencing Technology

Your DNA, your (full) health story

Whole Exome Sequencing (WES) is the latest in DNA analytic technology used by top medical groups and leading research centres, such as the UK’s NHS, Harvard University, and Stanford University. It’s a state-of-the-art tool that allows rapid sequencing of large amounts of DNA information.

Imagine that every gene is like a book. Traditional genotyping technology analyses your genes by looking at the equivalent of just a few sentences – but without reading the entire book, you won’t know the full story of what’s happening. With Whole Exome Sequencing (WES) technology, we’re able to produce reports that summarize the whole book of your health – not just a few sentences.

Why read just a sentence when you can read the whole book?

	Traditional Genotyping Technology As an example, recreational tests only look at a few variants of the BRCA 1/2 gene, which creates a high likelihood of producing a false-positive result.	Whole Exome Sequencing Technology Meanwhile, CircleDNA looks at the whole “book” for the BRCA 1/2 gene, covering 5,791 known variants that affect your risk of breast and ovarian cancer.
Number of genetic data points	Hundreds of thousands	> 31 million
Sampling data volume	Dozens of MB	Several GB
Device	Microarray scanner	Novaseq (next generation sequencing)
Ability to detect new mutations?	No	Yes